R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma

R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma

Propranolol is an approved non-selective β-adrenergic blocker that is first line therapy for infantile hemangioma. Despite the clinical benefit of propranolol therapy in hemangioma, the mechanistic understanding of what drives this outcome is limited. Here, we report successful treatment of pericard...

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Bibliographic Details
Main Authors: Jeroen Overman, Frank Fontaine, Jill Wylie-Sears, Mehdi Moustaqil, Lan Huang, Marie Meurer, Ivy Kim Chiang, Emmanuelle Lesieur, Jatin Patel, Johannes Zuegg, Eddy Pasquier, Emma Sierecki, Yann Gambin, Mohamed Hamdan, Kiarash Khosrotehrani, Gregor Andelfinger, Joyce Bischoff, Mathias Francois
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
protein-protein interaction
transcription factors
rare disease
gene expression
hemangioma
propranolol enantiomer
Online Access:https://elifesciences.org/articles/43026

Internet

https://elifesciences.org/articles/43026

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