Geldanamycin-Induced Phosphatidylserine Translocation in the Erythrocyte Membrane

Geldanamycin-Induced Phosphatidylserine Translocation in the Erythrocyte Membrane

Background/aims: Geldanamycin, a benzoquinone ansamycin antibiotic, and its analogues induce apoptosis of tumor cells and are thus considered for the treatment of cancer. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal erythrocyte death characterized by cell s...

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Bibliographic Details
Main Authors: Kashif Jilani, Syed M. Qadri, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Phosphatidylserine
Geldanamycin
Calcium
Ceramide
Cell volume
Eryptosis
Online Access:http://www.karger.com/Article/FullText/356596

Internet

http://www.karger.com/Article/FullText/356596

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