PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

Summary: Dendritic cells (DCs) orchestrate the initiation, programming, and regulation of anti-tumor immune responses. Emerging evidence indicates that the tumor microenvironment (TME) induces immune dysfunctional tumor-infiltrating DCs (TIDCs), characterized with both increased intracellular lipid...

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Bibliographic Details
Main Authors: Xiaozhe Yin, Wenfeng Zeng, Bowen Wu, Luoyang Wang, Zihao Wang, Hongjian Tian, Luyao Wang, Yunhan Jiang, Ryan Clay, Xiuli Wei, Yan Qin, Fayun Zhang, Chunling Zhang, Lingtao Jin, Wei Liang
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
dendritic cell
DC
tumor-derived exosome
PPARα
lipid metabolism
immune dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312675

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http://www.sciencedirect.com/science/article/pii/S2211124720312675

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