Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma

Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma

The tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages.

Bibliographic Details
Main Authors: Weiwei Tao, Chengwei Chu, Wenchao Zhou, Zhi Huang, Kui Zhai, Xiaoguang Fang, Qian Huang, Aili Zhang, Xiuxing Wang, Xingjiang Yu, Haidong Huang, Qiulian Wu, Andrew E. Sloan, Jennifer S. Yu, Xiaoxia Li, George R. Stark, Jeremy N. Rich, Shideng Bao
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16827-z
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spelling doaj-80ed06b6daa44b72a61177b8c8e470662021-06-20T11:14:12ZengNature Publishing GroupNature Communications2041-17232020-06-0111111610.1038/s41467-020-16827-zDual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastomaWeiwei Tao0Chengwei Chu1Wenchao Zhou2Zhi Huang3Kui Zhai4Xiaoguang Fang5Qian Huang6Aili Zhang7Xiuxing Wang8Xingjiang Yu9Haidong Huang10Qiulian Wu11Andrew E. Sloan12Jennifer S. Yu13Xiaoxia Li14George R. Stark15Jeremy N. Rich16Shideng Bao17Department of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDivision of Regenerative Medicine, Department of Medicine, University of California, San DiegoDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDivision of Regenerative Medicine, Department of Medicine, University of California, San DiegoBrain Tumor and Neuro-Oncology Center, Seidman Cancer Center, University Hospitals, Case Western Reserve UniversityDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicCase Comprehensive Cancer Center, Case Western Reserve University School of MedicineDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDivision of Regenerative Medicine, Department of Medicine, University of California, San DiegoDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicThe tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages.https://doi.org/10.1038/s41467-020-16827-z
collection DOAJ
language English
format Article
sources DOAJ
author Weiwei Tao
Chengwei Chu
Wenchao Zhou
Zhi Huang
Kui Zhai
Xiaoguang Fang
Qian Huang
Aili Zhang
Xiuxing Wang
Xingjiang Yu
Haidong Huang
Qiulian Wu
Andrew E. Sloan
Jennifer S. Yu
Xiaoxia Li
George R. Stark
Jeremy N. Rich
Shideng Bao
spellingShingle Weiwei Tao
Chengwei Chu
Wenchao Zhou
Zhi Huang
Kui Zhai
Xiaoguang Fang
Qian Huang
Aili Zhang
Xiuxing Wang
Xingjiang Yu
Haidong Huang
Qiulian Wu
Andrew E. Sloan
Jennifer S. Yu
Xiaoxia Li
George R. Stark
Jeremy N. Rich
Shideng Bao
Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
Nature Communications
author_facet Weiwei Tao
Chengwei Chu
Wenchao Zhou
Zhi Huang
Kui Zhai
Xiaoguang Fang
Qian Huang
Aili Zhang
Xiuxing Wang
Xingjiang Yu
Haidong Huang
Qiulian Wu
Andrew E. Sloan
Jennifer S. Yu
Xiaoxia Li
George R. Stark
Jeremy N. Rich
Shideng Bao
author_sort Weiwei Tao
title Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
title_short Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
title_full Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
title_fullStr Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
title_full_unstemmed Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
title_sort dual role of wisp1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description The tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages.
url https://doi.org/10.1038/s41467-020-16827-z
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