LmaPA2G4, a homolog of human Ebp1, is an essential gene and inhibits cell proliferation in L. major.

We have identified LmaPA2G4, a homolog of the human proliferation-associated 2G4 protein (also termed Ebp1), in a phosphoproteomic screening. Multiple sequence alignment and cluster analysis revealed that LmaPA2G4 is a non-peptidase member of the M24 family of metallopeptidases. This pseudoenzyme is...

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Bibliographic Details
Main Authors: Brianna Norris-Mullins, Kaitlin VanderKolk, Paola Vacchina, Michelle V Joyce, Miguel A Morales
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3888471?pdf=render