Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

Previously we reported that Src-associated-substrate-during-mitosis-of-68kDa (Sam68/KHDRBS1) is pivotal for DNA damage-stimulated NF-κB transactivation of anti-apoptotic genes (Fu et al., 2016). Here we show that Sam68 is critical for genotoxic stress-induced NF-κB activation in the γ-irradiated col...

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Bibliographic Details
Main Authors: Kai Fu, Xin Sun, Eric M Wier, Andrea Hodgson, Ryan P Hobbs, Fengyi Wan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
Sam68
KHDRBS1
radiodamage
NF-κB
colon epithelium
Online Access:https://elifesciences.org/articles/21957

Internet

https://elifesciences.org/articles/21957

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