Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
The iRGD tumor-penetrating peptide can achieve tumor specific drug delivery but whether and how it can penetrate into desmoplastic tumors is unknown. Here, the authors show that β5 integrin expression on tumor cells, mediated by CAFs-derived TGF-β, is required for iRGD penetration into the desmoplas...
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2021-03-01
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Online Access: | https://doi.org/10.1038/s41467-021-21858-1 |
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doaj-80f9f85745054067b544050e7b18b6702021-03-11T11:33:46ZengNature Publishing GroupNature Communications2041-17232021-03-0112111310.1038/s41467-021-21858-1Tumor-penetrating therapy for β5 integrin-rich pancreas cancerTatiana Hurtado de Mendoza0Evangeline S. Mose1Gregory P. Botta2Gary B. Braun3Venkata R. Kotamraju4Randall P. French5Kodai Suzuki6Norio Miyamura7Tambet Teesalu8Erkki Ruoslahti9Andrew M. Lowy10Kazuki N. Sugahara11Cancer Research Center, Sanford-Burnham-Prebys Medical Discovery InstituteDepartment of Surgery, Division of Surgical Oncology, Moores Cancer Center, University of CaliforniaCancer Research Center, Sanford-Burnham-Prebys Medical Discovery InstituteCancer Research Center, Sanford-Burnham-Prebys Medical Discovery InstituteCancer Research Center, Sanford-Burnham-Prebys Medical Discovery InstituteDepartment of Surgery, Division of Surgical Oncology, Moores Cancer Center, University of CaliforniaDepartment of Surgery, Columbia University Vagelos College of Physicians and SurgeonsDepartment of Surgery, Columbia University Vagelos College of Physicians and SurgeonsCancer Research Center, Sanford-Burnham-Prebys Medical Discovery InstituteCancer Research Center, Sanford-Burnham-Prebys Medical Discovery InstituteDepartment of Surgery, Division of Surgical Oncology, Moores Cancer Center, University of CaliforniaCancer Research Center, Sanford-Burnham-Prebys Medical Discovery InstituteThe iRGD tumor-penetrating peptide can achieve tumor specific drug delivery but whether and how it can penetrate into desmoplastic tumors is unknown. Here, the authors show that β5 integrin expression on tumor cells, mediated by CAFs-derived TGF-β, is required for iRGD penetration into the desmoplastic PDAC microenvironment and that iRGD-based combination therapy is effective in PDAC mouse models.https://doi.org/10.1038/s41467-021-21858-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tatiana Hurtado de Mendoza Evangeline S. Mose Gregory P. Botta Gary B. Braun Venkata R. Kotamraju Randall P. French Kodai Suzuki Norio Miyamura Tambet Teesalu Erkki Ruoslahti Andrew M. Lowy Kazuki N. Sugahara |
spellingShingle |
Tatiana Hurtado de Mendoza Evangeline S. Mose Gregory P. Botta Gary B. Braun Venkata R. Kotamraju Randall P. French Kodai Suzuki Norio Miyamura Tambet Teesalu Erkki Ruoslahti Andrew M. Lowy Kazuki N. Sugahara Tumor-penetrating therapy for β5 integrin-rich pancreas cancer Nature Communications |
author_facet |
Tatiana Hurtado de Mendoza Evangeline S. Mose Gregory P. Botta Gary B. Braun Venkata R. Kotamraju Randall P. French Kodai Suzuki Norio Miyamura Tambet Teesalu Erkki Ruoslahti Andrew M. Lowy Kazuki N. Sugahara |
author_sort |
Tatiana Hurtado de Mendoza |
title |
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer |
title_short |
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer |
title_full |
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer |
title_fullStr |
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer |
title_full_unstemmed |
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer |
title_sort |
tumor-penetrating therapy for β5 integrin-rich pancreas cancer |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-03-01 |
description |
The iRGD tumor-penetrating peptide can achieve tumor specific drug delivery but whether and how it can penetrate into desmoplastic tumors is unknown. Here, the authors show that β5 integrin expression on tumor cells, mediated by CAFs-derived TGF-β, is required for iRGD penetration into the desmoplastic PDAC microenvironment and that iRGD-based combination therapy is effective in PDAC mouse models. |
url |
https://doi.org/10.1038/s41467-021-21858-1 |
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