A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses

A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses

Breast cancer (BC) is the most common cancer among women worldwide. More than 70% of BC cases express estrogen receptor alpha (ERα), a central transcription factor that stimulates the proliferation of breast cancer cells, usually in the presence of estrogen. While most cases of ER-positive BC initia...

Full description

Bibliographic Details
Main Authors: Léa Clusan, Pascale Le Goff, Gilles Flouriot, Farzad Pakdel
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
estrogen receptor
breast cancer
endocrine resistance
mutation
receptor folding
Online Access:https://www.mdpi.com/1422-0067/22/2/756

Internet

https://www.mdpi.com/1422-0067/22/2/756

Similar Items