AAV-Mediated Expression of AP-1-Neutralizing RNA Decoy Oligonucleotides Attenuates Transplant Vasculopathy in Mouse Aortic Allografts

AAV-Mediated Expression of AP-1-Neutralizing RNA Decoy Oligonucleotides Attenuates Transplant Vasculopathy in Mouse Aortic Allografts

Transplant vasculopathy (TV), characterized by obstructive lesions in affected vessels, represents one of the long-term complications of cardiac transplantation. Activation of the transcription factor activator protein-1 (AP-1) is implicated in smooth muscle cell (SMC) phenotypic switch from contrac...

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Bibliographic Details
Main Authors: Anca Remes, Maximilian Franz, Franziska Mohr, Antje Weber, Kleopatra Rapti, Andreas Jungmann, Matthias Karck, Markus Hecker, Klaus Kallenbach, Oliver J. Müller, Rawa Arif, Andreas H. Wagner
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S232905011930107X

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http://www.sciencedirect.com/science/article/pii/S232905011930107X

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