Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover.

Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover.

Schistosomes express a family of integral membrane proteins, called tetraspanins (TSPs), in the outer surface membranes of the tegument. Two of these tetraspanins, Sm-TSP-1 and Sm-TSP-2, confer protection as vaccines in mice, and individuals who are naturally resistant to S. mansoni infection mount...

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Bibliographic Details
Main Authors: Mai H Tran, Tori C Freitas, Leanne Cooper, Soraya Gaze, Michelle L Gatton, Malcolm K Jones, Erica Lovas, Edward J Pearce, Alex Loukas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2855321?pdf=render

Internet

http://europepmc.org/articles/PMC2855321?pdf=render

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