Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover.
Schistosomes express a family of integral membrane proteins, called tetraspanins (TSPs), in the outer surface membranes of the tegument. Two of these tetraspanins, Sm-TSP-1 and Sm-TSP-2, confer protection as vaccines in mice, and individuals who are naturally resistant to S. mansoni infection mount...
Main Authors: | Mai H Tran, Tori C Freitas, Leanne Cooper, Soraya Gaze, Michelle L Gatton, Malcolm K Jones, Erica Lovas, Edward J Pearce, Alex Loukas |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-04-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2855321?pdf=render |
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