Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels

Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels

Enoxaparin (Enox), a low molecular weight heparin, has been shown to lower brain amyloid β (Aβ) load in a mouse model for Alzheimer's disease. However, the effect of Enox on cognition was not studied. Therefore, we examined the effect of peripheral Enox treatment on cognition and brain Aβ level...

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Bibliographic Details
Main Authors: Nienke M. Timmer, Laura van Dijk, Catharina E.E.M. van der Zee, Amanda Kiliaan, Robert M.W de Waal, Marcel M. Verbeek
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid β
Transgenic mice
Enoxaparin
Treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002044

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110002044

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