The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level

The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level

Abstract Background The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency. RNA surveillance proteins such as UPF1, UPF2 and SMG6 affect RNA stab...

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Bibliographic Details
Main Authors: Shringar Rao, Raquel Amorim, Meijuan Niu, Abdelkrim Temzi, Andrew J. Mouland
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Retrovirology
Subjects:
HIV-1 latency
RNA surveillance proteins
HIV-1 genomic RNA stability
Post-transcriptional regulation
Nonsense-mediated mRNA decay
NMD
Online Access:http://link.springer.com/article/10.1186/s12977-018-0425-2

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http://link.springer.com/article/10.1186/s12977-018-0425-2

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