The impact of ICAM-1, CCL2 and TGM2 gene polymorphisms on differentiation syndrome in acute promyelocytic leukemia

The impact of ICAM-1, CCL2 and TGM2 gene polymorphisms on differentiation syndrome in acute promyelocytic leukemia

Abstract Background Although arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) are well-tolerated and effective treatments for Acute Promyelocytic Leukemia (APL), Differentiation Syndrome (DS) is a lethal side effect in some patients. The pathogenesis of DS is complex and not well understood...

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Bibliographic Details
Main Authors: Zahra Mohammadzadeh, Azadeh Omidkhoda, Bahram Chahardouli, Ghazaleh Hoseinzadeh, Kamran Ali Moghaddam, Seyed Asadollah Mousavi, Shahrbano Rostami
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Cancer
Subjects:
Acute Promyelocytic leukemia
Differentiation syndrome
ICAM-1
CCL2 chemokine
Transglutaminase II
SNPs
Online Access:https://doi.org/10.1186/s12885-021-07783-y

Internet

https://doi.org/10.1186/s12885-021-07783-y

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