Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

Small interfering RNAs (siRNAs) have potential to silence virtually any disease-causing gene but require chemical modifications for delivery to the tissue and cell of interest. Previously, we demonstrated that asymmetric, phosphorothioate (PS)-modified, chemically stabilized, cholesterol-conjugated...

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Bibliographic Details
Main Authors: Socheata Ly, Dimas Echeverria, Jacquelyn Sousa, Anastasia Khvorova
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
siRNAs
chemically modified siRNAs
cholesterol conjugated siRNAs
siRNA trafficking
phosphorothioate
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302183

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http://www.sciencedirect.com/science/article/pii/S2162253120302183

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