Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics

Recent human studies suggest a role for altered oligodendrocytes in the pathophysiology of schizophrenia. Our recent animal study has reported some schizophrenia-like behaviors in mice exposed to cuprizone (Xu et al., 2009), a copper chelator that has been shown to selectively damage the white matte...

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Bibliographic Details
Main Authors: Haiyun Xu, Hong Yang, Bryan McConomy, Ronald A Browning, Xin-Min Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
MBP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2010.00008/full