Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair

Dense connective tissues do not easily heal, in part due to a low supply of reparative cells. Here, the authors develop a fibrous scaffold for meniscal repair that sequentially releases collagenase and a growth factor at the injury site, breaking down the extracellular matrix and recruiting endogeno...

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Bibliographic Details
Main Authors: Feini Qu, Julianne L. Holloway, John L. Esterhai, Jason A. Burdick, Robert L. Mauck
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01955-w