Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation

Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation

Evidence indicates that dysfunctional heterogeneous ribonucleoprotein A1 (hnRNPA1; A1) contributes to the pathogenesis of neurodegeneration in multiple sclerosis. Understanding molecular mechanisms of neurodegeneration in multiple sclerosis may result in novel therapies that attenuate neurodegenerat...

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Bibliographic Details
Main Authors: Joseph-Patrick W. E. Clarke, Patricia A. Thibault, Hannah E. Salapa, David E. Kim, Catherine Hutchinson, Michael C. Levin
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
hnRNPA1
mutations
optogenetics
stress granules
multiple sclerosis
Online Access:https://www.mdpi.com/1422-0067/22/6/2909

Internet

https://www.mdpi.com/1422-0067/22/6/2909

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