Improved oral absorption and anti-lung cancer activity of paclitaxel-loaded mixed micelles

Improved oral absorption and anti-lung cancer activity of paclitaxel-loaded mixed micelles

The aim of this study was to establish a paclitaxel (PTX)-loaded mixed micelle delivery system (PTX-TP-M) with vitamin E-TPGS (TPGS) and Plasdone®S-630 Copovidone (PVPS630) as carriers to improve the solubility, oral absorption, and anti-tumor activity of PTX against lung cancer. In this study, PTX-...

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Bibliographic Details
Main Authors: Jian Hou, E. Sun, Zhen-Hai Zhang, Jing Wang, Lei Yang, Li Cui, Zhong-Cheng Ke, Xiao-Bin Tan, Xiao-Bin Jia, Huixia Lv
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
paclitaxel
vitamin e-tpgs
plasdone®s-630 copovidone
micelles
oral bioavailability
caco-2 monolayer
anti-tumor
gastrointestinal safety assay
Online Access:http://dx.doi.org/10.1080/10717544.2016.1245370

Internet

http://dx.doi.org/10.1080/10717544.2016.1245370

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