Combination Treatment of CI-994 With Etoposide Potentiates Anticancer Effects Through a Topoisomerase II-Dependent Mechanism in Atypical Teratoid/Rhabdoid Tumor (AT/RT)

Combination Treatment of CI-994 With Etoposide Potentiates Anticancer Effects Through a Topoisomerase II-Dependent Mechanism in Atypical Teratoid/Rhabdoid Tumor (AT/RT)

PurposeAtypical teratoid/rhabdoid tumor (AT/RT) is arising typically in young children and is associated with a dismal prognosis which there is currently no curative chemotherapeutic regimen. Based on previous studies showing high histone deacetylase 1 (HDAC1) expression in AT/RT, the HDAC1 inhibito...

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Bibliographic Details
Main Authors: Hee Yeon Kim, Seung Ah Choi, Eun Jung Koh, Kyung Hyun Kim, Ji Hoon Phi, Ji Yeoun Lee, Seung-Ki Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
atypical teratoid/rhabdoid tumor
combination treatment
HDAC1 inhibition
synergism
topoisomerase II
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.648023/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.648023/full

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