Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is an oligomeric enzyme with crucial roles in neuronal signaling and cardiac function. Previously, we showed that activation of CaMKII triggers the exchange of subunits between holoenzymes, potentially increasing the spread of the active state (St...

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Bibliographic Details
Main Authors: Deepti Karandur, Moitrayee Bhattacharyya, Zijie Xia, Young Kwang Lee, Serena Muratcioglu, Darren McAffee, Ethan D McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams, John Kuriyan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
CaMKII
activation-dependent disassembly
spread of activation state
molecular dynamics simulation
native mass spectrometry
Online Access:https://elifesciences.org/articles/57784

Internet

https://elifesciences.org/articles/57784

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