In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts.
CD8+ T-cell responses exert strong suppressive pressure on HIV replication and select for viral escape mutations. Some of these major histocompatibility complex class I (MHC-I)-associated mutations result in reduction of in vitro viral replicative capacity. While these mutations can revert after vir...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-09-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5624644?pdf=render |