In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts.

In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts.

CD8+ T-cell responses exert strong suppressive pressure on HIV replication and select for viral escape mutations. Some of these major histocompatibility complex class I (MHC-I)-associated mutations result in reduction of in vitro viral replicative capacity. While these mutations can revert after vir...

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Bibliographic Details
Main Authors: Sayuri Seki, Takushi Nomura, Masako Nishizawa, Hiroyuki Yamamoto, Hiroshi Ishii, Saori Matsuoka, Teiichiro Shiino, Hironori Sato, Kazuta Mizuta, Hiromi Sakawaki, Tomoyuki Miura, Taeko K Naruse, Akinori Kimura, Tetsuro Matano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5624644?pdf=render

Internet

http://europepmc.org/articles/PMC5624644?pdf=render

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