Inhibition of mycobacterial CYP125 enzyme by sesamin and β-sitosterol: An in silico and in vitro study

Inhibition of mycobacterial CYP125 enzyme by sesamin and β-sitosterol: An in silico and in vitro study

Background: Cholesterol degradation pathway is one of the important pathways in survival of Mycobacterium tuberculosis (Mtb) bacilli, and steroid C26-monooxygenase (CYP125) enzyme of Mtb associated with this pathway is reported to be novel drug target. This study aims to find out novel, safe, and ef...

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Bibliographic Details
Main Authors: Gauri Wankhade, Sarika Kamble, Shraddha Deshmukh, Lingaraja Jena, Pranita Waghmare, Bhaskar C Harinath
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Biomedical and Biotechnology Research Journal
Subjects:
Minimum inhibitory concentration
molecular dynamics simulation
Mycobacterium tuberculosis
phytochemicals
virtual screening
Online Access:http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2017;volume=1;issue=1;spage=49;epage=54;aulast=Wankhade

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http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2017;volume=1;issue=1;spage=49;epage=54;aulast=Wankhade

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