Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells

Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells

There is increased interest in using high throughput in vitro assays to characterize human population variability in response to toxicants and drugs. Utilizing primary human endothelial colony-forming cells (ECFCs) isolated from blood would be highly useful for this purpose because these cells are i...

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Bibliographic Details
Main Authors: Daria Filonov, Raymond Tice, Ruiyan Luo, Chad Grotegut, Michael J. Van Kanegan, John W. Ludlow, Dora Il'yasova, Alexander Kinev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Public Health
Subjects:
toxicological risk assessment
animal replacement
population variability
endothelial cells
developmental toxicants
cardiovascular disease
Online Access:https://www.frontiersin.org/article/10.3389/fpubh.2018.00369/full

Internet

https://www.frontiersin.org/article/10.3389/fpubh.2018.00369/full

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