What is the therapeutic mechanism of pedunculopontine nucleus stimulation in Parkinson's disease?

Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) is an experimental treatment for Parkinson's disease (PD) which offers a fairly circumscribed benefit for gait freezing and perhaps balance impairment. The benefit on gait freezing is variable and typically incomplete, which may reflec...

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Bibliographic Details
Main Authors: Wesley Thevathasan, Elena Moro
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301931