A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia

A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia

Apelin and AVP have opposing effects water balance in humans and rodents. Here, the authors report that a metabolically stable apelin-17 analog, by acting at the kidney level, reduces AVP-induced antidiuresis and improves hyponatremia in rodents, demonstrating a potential approach for treating water...

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Bibliographic Details
Main Authors: Adrien Flahault, Pierre-Emmanuel Girault-Sotias, Mathilde Keck, Rodrigo Alvear-Perez, Nadia De Mota, Lucie Estéoulle, Sridévi M. Ramanoudjame, Xavier Iturrioz, Dominique Bonnet, Catherine Llorens-Cortes
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20560-y

Internet

https://doi.org/10.1038/s41467-020-20560-y

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