A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia

A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia

Apelin and AVP have opposing effects water balance in humans and rodents. Here, the authors report that a metabolically stable apelin-17 analog, by acting at the kidney level, reduces AVP-induced antidiuresis and improves hyponatremia in rodents, demonstrating a potential approach for treating water...

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Main Authors: Adrien Flahault, Pierre-Emmanuel Girault-Sotias, Mathilde Keck, Rodrigo Alvear-Perez, Nadia De Mota, Lucie Estéoulle, Sridévi M. Ramanoudjame, Xavier Iturrioz, Dominique Bonnet, Catherine Llorens-Cortes
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20560-y
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spelling doaj-813075a60acd4a2aae6dfe98df5633102021-01-17T12:12:31ZengNature Publishing GroupNature Communications2041-17232021-01-0112111410.1038/s41467-020-20560-yA metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremiaAdrien Flahault0Pierre-Emmanuel Girault-Sotias1Mathilde Keck2Rodrigo Alvear-Perez3Nadia De Mota4Lucie Estéoulle5Sridévi M. Ramanoudjame6Xavier Iturrioz7Dominique Bonnet8Catherine Llorens-Cortes9Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Center for Interdisciplinary Research in Biology, INSERM, Unit U1050, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7241, Collège de FranceLaboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Center for Interdisciplinary Research in Biology, INSERM, Unit U1050, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7241, Collège de FranceLaboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Center for Interdisciplinary Research in Biology, INSERM, Unit U1050, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7241, Collège de FranceLaboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Center for Interdisciplinary Research in Biology, INSERM, Unit U1050, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7241, Collège de FranceLaboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Center for Interdisciplinary Research in Biology, INSERM, Unit U1050, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7241, Collège de FranceLaboratory of Therapeutic Innovation, Unité Mixte de Recherche 7200, Centre National de la Recherche Scientifique, Faculty of Pharmacy, University of StrasbourgLaboratory of Therapeutic Innovation, Unité Mixte de Recherche 7200, Centre National de la Recherche Scientifique, Faculty of Pharmacy, University of StrasbourgLaboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Center for Interdisciplinary Research in Biology, INSERM, Unit U1050, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7241, Collège de FranceLaboratory of Therapeutic Innovation, Unité Mixte de Recherche 7200, Centre National de la Recherche Scientifique, Faculty of Pharmacy, University of StrasbourgLaboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Center for Interdisciplinary Research in Biology, INSERM, Unit U1050, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7241, Collège de FranceApelin and AVP have opposing effects water balance in humans and rodents. Here, the authors report that a metabolically stable apelin-17 analog, by acting at the kidney level, reduces AVP-induced antidiuresis and improves hyponatremia in rodents, demonstrating a potential approach for treating water metabolism disorders.https://doi.org/10.1038/s41467-020-20560-y
collection DOAJ
language English
format Article
sources DOAJ
author Adrien Flahault
Pierre-Emmanuel Girault-Sotias
Mathilde Keck
Rodrigo Alvear-Perez
Nadia De Mota
Lucie Estéoulle
Sridévi M. Ramanoudjame
Xavier Iturrioz
Dominique Bonnet
Catherine Llorens-Cortes
spellingShingle Adrien Flahault
Pierre-Emmanuel Girault-Sotias
Mathilde Keck
Rodrigo Alvear-Perez
Nadia De Mota
Lucie Estéoulle
Sridévi M. Ramanoudjame
Xavier Iturrioz
Dominique Bonnet
Catherine Llorens-Cortes
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
Nature Communications
author_facet Adrien Flahault
Pierre-Emmanuel Girault-Sotias
Mathilde Keck
Rodrigo Alvear-Perez
Nadia De Mota
Lucie Estéoulle
Sridévi M. Ramanoudjame
Xavier Iturrioz
Dominique Bonnet
Catherine Llorens-Cortes
author_sort Adrien Flahault
title A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
title_short A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
title_full A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
title_fullStr A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
title_full_unstemmed A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
title_sort metabolically stable apelin-17 analog decreases avp-induced antidiuresis and improves hyponatremia
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description Apelin and AVP have opposing effects water balance in humans and rodents. Here, the authors report that a metabolically stable apelin-17 analog, by acting at the kidney level, reduces AVP-induced antidiuresis and improves hyponatremia in rodents, demonstrating a potential approach for treating water metabolism disorders.
url https://doi.org/10.1038/s41467-020-20560-y
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