Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

The use of cannabis is rapidly expanding worldwide. Thus, innovative studies aimed to identify, understand and potentially reduce cannabis-evoked harms are warranted. Here, we found that Δ9-tetrahydrocannabinol, the psychoactive ingredient of cannabis, disrupts autophagy selectively in the striatum,...

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Bibliographic Details
Main Authors: Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, Jérôme M Baufreton, Eva Resel, Marjorie Varilh, Antonio C Pagano Zottola, Yamuna Mariani, Astrid Cannich, José A Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
cannabinoid
striatum
motor behaviour
drug abuse
autophagy
mTOR
Online Access:https://elifesciences.org/articles/56811

Internet

https://elifesciences.org/articles/56811

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