Expression and Prognostic Significance of CD47–SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer

Expression and Prognostic Significance of CD47–SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer

Despite the confirmed anti-cancer effects of T-cell immune checkpoint inhibitors, in colorectal cancer (CRC) they are only effective in a small subset of patients with microsatellite-unstable tumors. Thus, therapeutics targeting other types of CRCs or tumors refractory to T-cell checkpoint inhibitor...

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Bibliographic Details
Main Authors: Akane Sugimura-Nagata, Akira Koshino, Satoshi Inoue, Aya Matsuo-Nagano, Masayuki Komura, Miho Riku, Hideaki Ito, Akihito Inoko, Hideki Murakami, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Satoru Takahashi, Kunio Kasugai, Kenji Kasai, Shingo Inaguma
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer (CRC)
immunohistochemistry
macrophage checkpoint
CD47
signal regulatory protein-alpha (SIRPA)
Online Access:https://www.mdpi.com/1422-0067/22/5/2690

Internet

https://www.mdpi.com/1422-0067/22/5/2690

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