Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

Hearing and balance involve the transduction of mechanical stimuli into electrical signals by deflection of bundles of stereocilia linked together by protocadherin 15 (PCDH15) and cadherin 23 ‘tip links’. PCDH15 transduces tip link tension into opening of a mechano-electrical transduction (MET) ion...

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Bibliographic Details
Main Authors: Jingpeng Ge, Johannes Elferich, April Goehring, Huaying Zhao, Peter Schuck, Eric Gouaux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
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Online Access:https://elifesciences.org/articles/38770