Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress

Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress

Group IIA secretory phospholipase A2 (sPLA2) is an acute-phase protein mediating decreased plasma HDL cholesterol and increased atherosclerosis. This study investigated the impact of macrophage-specific sPLA2 overexpression on lipoprotein metabolism and atherogenesis. Macrophages from sPLA2 transgen...

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Bibliographic Details
Main Authors: Uwe J.F. Tietge, Domenico Pratico, Tao Ding, Colin D. Funk, Reeni B. Hildebrand, Theo Van Berkel, Miranda Van Eck
Format: Article
Language:English
Published: Elsevier 2005-08-01
Series:Journal of Lipid Research
Subjects:
secretory phospholipase A2
lipoxygenase
hypercholesterolemia
inflammation
lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752032959X

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http://www.sciencedirect.com/science/article/pii/S002222752032959X

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