Interferon-γ induces microglial-activation-induced cell death: A hypothetical mechanism of relapse and remission in multiple sclerosis

Interferon-γ induces microglial-activation-induced cell death: A hypothetical mechanism of relapse and remission in multiple sclerosis

Relapse and remission are characteristics of multiple sclerosis (MS). The underlying mechanisms, however, remain uncertain. Interferon-γ (IFN-γ) disturbs the immunological privilege of the central nervous system (CNS) by inducing major histocompatibility complex antigen expression in CNS cells and a...

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Bibliographic Details
Main Authors: Hideyuki Takeuchi, Jinyan Wang, Jun Kawanokuchi, Norimasa Mitsuma, Tetsuya Mizuno, Akio Suzumura
Format: Article
Language:English
Published: Elsevier 2006-04-01
Series:Neurobiology of Disease
Subjects:
Microglia
Interferon-γ
Apoptosis
Activation-induced cell death
Bax
Multiple sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610500269X

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http://www.sciencedirect.com/science/article/pii/S096999610500269X

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