Indomethacin Disrupts the Formation of β-Amyloid Plaques via an α2-Macroglobulin-Activating lrp1-Dependent Mechanism

Indomethacin Disrupts the Formation of β-Amyloid Plaques via an α2-Macroglobulin-Activating lrp1-Dependent Mechanism

Epidemiological studies have implied that the nonsteroidal anti-inflammatory drug (NSAID) indomethacin slows the development and progression of Alzheimer’s disease (AD). However, the underlying mechanisms are notably understudied. Using a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695sw...

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Bibliographic Details
Main Authors: Pei-Pei Guan, Liu-Qing Yang, Guo-Biao Xu, Pu Wang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
indomethacin
α<sub>2</sub>-macroglobulin
low-density lipoprotein receptor-related protein 1
prostaglandin D<sub>2</sub> receptor 2
brain efflux of β-amyloid protein
Online Access:https://www.mdpi.com/1422-0067/22/15/8185

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https://www.mdpi.com/1422-0067/22/15/8185

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