Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported. Using an ultrasensitive and specific protein misfolding cyclic amplification–based assay for detecting variant CJD prions in cerebr...

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Bibliographic Details
Main Authors: Daisy Bougard, Maxime Bélondrade, Charly Mayran, Lilian Bruyère-Ostells, Sylvain Lehmann, Chantal Fournier-Wirth, Richard S. Knight, Robert G. Will, Alison J.E. Green
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2018-07-01
Series:Emerging Infectious Diseases
Subjects:
Creutzfeldt-Jakob disease
methionine/valine variant
cerebrospinal fluid
CSF
prions and related diseases
protein misfolding cyclic amplification
Online Access:https://wwwnc.cdc.gov/eid/article/24/7/17-2105_article

Internet

https://wwwnc.cdc.gov/eid/article/24/7/17-2105_article

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