BCR Affinity Influences T-B Interactions and B Cell Development in Secondary Lymphoid Organs

BCR Affinity Influences T-B Interactions and B Cell Development in Secondary Lymphoid Organs

B cells produce high-affinity immunoglobulins (Igs), or antibodies, to eliminate foreign pathogens. Mature, naïve B cells expressing an antigen-specific cell surface Ig, or B cell receptor (BCR), are directed toward either an extrafollicular (EF) or germinal center (GC) response upon antigen binding...

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Bibliographic Details
Main Authors: Alec J. Wishnie, Tzippora Chwat-Edelstein, Mary Attaway, Bao Q. Vuong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
BCR affinity
T follicular helper cells
germinal center
extrafollicular
B cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.703918/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.703918/full

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