Mutations in the polycomb group gene polyhomeotic lead to epithelial instability in both the ovary and wing imaginal disc in Drosophila.

Mutations in the polycomb group gene polyhomeotic lead to epithelial instability in both the ovary and wing imaginal disc in Drosophila.

BACKGROUND:Most human cancers originate from epithelial tissues and cell polarity and adhesion defects can lead to metastasis. The Polycomb-Group of chromatin factors were first characterized in Drosophila as repressors of homeotic genes during development, while studies in mammals indicate a conser...

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Bibliographic Details
Main Authors: Pierre Gandille, Karine Narbonne-Reveau, Elisabeth Boissonneau, Neel Randsholt, Denise Busson, Anne-Marie Pret
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2978711?pdf=render

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http://europepmc.org/articles/PMC2978711?pdf=render

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