6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression

6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression

Abstract Background Anti-angiogenic therapies demonstrate anti-tumor effects by decreasing blood supply to tumors and inhibiting tumor growth. However, anti-angiogenic therapy may leads to changes in tumor microenvironment and increased invasiveness of tumor cells, which in turn promotes distant met...

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Bibliographic Details
Main Authors: Weilong Zhong, Wendong Yang, Yuan Qin, Wenguang Gu, Yinyin Xue, Yuanhao Tang, Hengwei Xu, Hongzhi Wang, Chao Zhang, Changhua Wang, Bo Sun, Yanrong Liu, Huijuan Liu, Honggang Zhou, Shuang Chen, Tao Sun, Cheng Yang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Microvascular structural entropy
6-gingerol
Tumor vessel normalization
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s13046-019-1291-z

Internet

http://link.springer.com/article/10.1186/s13046-019-1291-z

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