The Recombinant Protein Based on Trypanosoma cruzi P21 Interacts With CXCR4 Receptor and Abrogates the Invasive Phenotype of Human Breast Cancer Cells

The Recombinant Protein Based on Trypanosoma cruzi P21 Interacts With CXCR4 Receptor and Abrogates the Invasive Phenotype of Human Breast Cancer Cells

Trypanosoma cruzi P21 is a protein secreted by the parasite that plays biological roles directly involved in the progression of Chagas disease. The recombinant protein (rP21) demonstrates biological properties, such as binding to CXCR4 receptors in macrophages, chemotactic activity of immune cells,...

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Main Authors: Bruna Cristina Borges, Isadora Akemi Uehara, Marlus Alves dos Santos, Flávia Alves Martins, Fernanda Carvalho de Souza, Álvaro Ferreira Junior, Felipe Andrés Cordero da Luz, Mylla Spirandelli da Costa, Ana Flávia Oliveira Notário, Daiana Silva Lopes, Samuel Cota Teixeira, Thaise Lara Teixeira, Patrícia de Castilhos, Claudio Vieira da Silva, Marcelo José Barbosa Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Trypanosoma cruzi
recombinant protein P21
CXCR4
triple-negative breast cancer cells
invasion cell
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.569729/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.569729/full

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