MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. However, there still remains a lack of effective diagnostic and therapeutic targets for this disease. Increasing evidence demonstrates that RNA modifications play an important role in the progression of HCC, bu...

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Bibliographic Details
Main Authors: Peng Xia, Hao Zhang, Kequan Xu, Xiang Jiang, Meng Gao, Ganggang Wang, Yingyi Liu, Ye Yao, Xi Chen, Weijie Ma, Zhonglin Zhang, Yufeng Yuan
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03973-5

Internet

https://doi.org/10.1038/s41419-021-03973-5

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