High-throughput sequencing of human immunoglobulin variable regions with subtype identification.

The humoral immune response plays a critical role in controlling infection, and the rapid adaptation to a broad range of pathogens depends on a highly diverse antibody repertoire. The advent of high-throughput sequencing technologies in the past decade has enabled insights into this immense diversit...

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Bibliographic Details
Main Authors: Merle Schanz, Thomas Liechti, Osvaldo Zagordi, Enkelejda Miho, Sai T Reddy, Huldrych F Günthard, Alexandra Trkola, Michael Huber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4218849?pdf=render