Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor.

Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor.

Metaplastic breast carcinoma (MBC) is a clinically aggressive and rare subtype of breast cancer, with similar features to basal-like breast cancers. Due to rapid growth rates and characteristic heterogeneity, MBC is often unresponsive to standard chemotherapies; and novel targeted therapeutic discov...

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Bibliographic Details
Main Authors: Tiffany C Chang, Margarite D Matossian, Steven Elliott, Hope E Burks, Rachel A Sabol, Deniz A Ucar, Henri Wathieu, Jovanny Zabaleta, Luis Del Valle, Sukhmani Gill, Elizabeth Martin, Adam I Riker, Lucio Miele, Bruce A Bunnell, Matthew E Burow, Bridgette M Collins-Burow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0226464

Internet

https://doi.org/10.1371/journal.pone.0226464

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