Identification of LPS-Activated Endothelial Subpopulations With Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms

Identification of LPS-Activated Endothelial Subpopulations With Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms

Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Endothelial cells (EC) are actively involved in sepsis-associated (micro)vascular disturbances and subsequent organ dysfunction. Lipopolysaccharide (LPS), a Gram-negative bacterial product, can activate EC le...

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Bibliographic Details
Main Authors: Erna-Zulaikha Dayang, Josée Plantinga, Bram ter Ellen, Matijs van Meurs, Grietje Molema, Jill Moser
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
endothelial cells
HUVEC
lipopolysaccharide (LPS)
adhesion molecules
endothelial heterogeneity
intracellular signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01169/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01169/full

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