1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice

1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice

1-Deoxynojirimycin (DNJ) is widely used for the treatment of diabetes mellitus as an inhibitor of intestinal α-glucosidase. However, there are few reports about its effect on insulin sensitivity improvement. The aim of the present study was to investigate whether DNJ decreased hyperglycemia by impro...

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Bibliographic Details
Main Authors: Qingpu Liu, Xuan Li, Cunyu Li, Yunfeng Zheng, Guoping Peng
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
mulberry leaves
1-deoxynojirimycin
db/db mice
insulin resistance
insulin signaling pathway
skeletal muscle
PI3K/AKT
GLUT4 translocation
Online Access:http://www.mdpi.com/1420-3049/20/12/19794

Internet

http://www.mdpi.com/1420-3049/20/12/19794

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