The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.

The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.

DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation, oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) intermediates. Several neurological diseases have already been identified as being due to a deficiency in DNA end-processing...

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Main Authors: Arpita Chatterjee, Saikat Saha, Anirban Chakraborty, Anabela Silva-Fernandes, Santi M Mandal, Andreia Neves-Carvalho, Yongping Liu, Raj K Pandita, Muralidhar L Hegde, Pavana M Hegde, Istvan Boldogh, Tetsuo Ashizawa, Arnulf H Koeppen, Tej K Pandita, Patricia Maciel, Partha S Sarkar, Tapas K Hazra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4310589?pdf=render

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http://europepmc.org/articles/PMC4310589?pdf=render

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