mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer

mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer

Ribonucleotide reductase (RNR) is the key enzyme that catalyzes the production of deoxyribonucleotides (dNTPs) for DNA replication and it is also essential for cancer cell proliferation. As the RNR inhibitor, Gemcitabine is widely used in cancer therapies, however, resistance limits its therapeutic...

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Bibliographic Details
Main Authors: Ling Tian, Congcong Chen, Yanguan Guo, Fan Zhang, Jinye Mi, Qi Feng, Shengbin Lin, Naite Xi, Jiaxin Tian, Li Yu, Yan Chen, Mingrong Cao, Caiyong Lai, Jun Fan, Yongchang Zhang, Guo Chen
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Ribonucleotide reductase
mTORC2
Gemcitabine
DNA replication stress
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000324

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http://www.sciencedirect.com/science/article/pii/S1476558621000324

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