Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells

Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells

Emerging evidence indicates important protective roles being played by autophagy in neurodegenerative disorders through clearance of aggregate-prone or mutant proteins. In the current study, we aimed to identify autophagy inducers from Chinese medicinal herbs as a potential neuroprotective agent tha...

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Bibliographic Details
Main Authors: An-Guo Wu, Vincent Kam-Wai Wong, Su-Wei Xu, Wai-Kit Chan, Choi-In Ng, Liang Liu, Betty Yuen-Kwan Law
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
Radix Polygalae
onjisaponin B
AMPK
mTOR
α-synuclein
huntingtin
PC-12
Online Access:http://www.mdpi.com/1422-0067/14/11/22618

Internet

http://www.mdpi.com/1422-0067/14/11/22618

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