Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.

Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.

Increased activity of single ventricular L-type Ca(2+)-channels (L-VDCC) is a hallmark in human heart failure. Recent findings suggest differential modulation by several auxiliary beta-subunits as a possible explanation.By molecular and functional analyses of human and murine ventricles, we find tha...

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Bibliographic Details
Main Authors: Roger Hullin, Jan Matthes, Sibylle von Vietinghoff, Ilona Bodi, Marta Rubio, Karen D'Souza, Ismail Friedrich Khan, Dennis Rottländer, Uta C Hoppe, Paul Mohacsi, Eva Schmitteckert, Ralf Gilsbach, Moritz Bünemann, Lutz Hein, Arnold Schwartz, Stefan Herzig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1808423?pdf=render

Internet

http://europepmc.org/articles/PMC1808423?pdf=render

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