Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.

Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.

Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus-receptor (CAR) on the surface of target cell for efficient transduction, which limits it's utility...

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Bibliographic Details
Main Authors: Di Yu, Chuan Jin, Mohanraj Ramachandran, Jing Xu, Berith Nilsson, Olle Korsgren, Katarina Le Blanc, Lene Uhrbom, Karin Forsberg-Nilsson, Bengt Westermark, Rachel Adamson, Norman Maitland, Xiaolong Fan, Magnus Essand
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3555985?pdf=render

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http://europepmc.org/articles/PMC3555985?pdf=render

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