Prolyl Hydroxylase 3 Knockdown Accelerates <i>VHL</i>-Mutant Kidney Cancer Growth In Vivo

Prolyl Hydroxylase 3 Knockdown Accelerates <i>VHL</i>-Mutant Kidney Cancer Growth In Vivo

Von Hippel Lindau (VHL) inactivation, which is common in clear cell renal cell carcinoma (ccRCC), leads directly to the disruption of oxygen homoeostasis. VHL works through hypoxia-inducible factors (HIFs). Within this VHL-HIF system, prolyl hydroxylases (PHDs) are the intermediary proteins that ini...

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Bibliographic Details
Main Authors: Niki M. Zacharias, Lei Wang, Tapati Maity, Li Li, Steven W. Millward, Jose A. Karam, Christopher G. Wood, Neema Navai
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
prolyl hydroxylases
renal cell carcinoma
hypoxia inducible factor 2α
Online Access:https://www.mdpi.com/1422-0067/22/6/2849

Internet

https://www.mdpi.com/1422-0067/22/6/2849

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