Flow Cytometric Determination of Actin Polymerization in Peripheral Blood Leukocytes Effectively Discriminate Patients With Homozygous Mutation in ARPC1B From Asymptomatic Carriers and Normal Controls

Flow Cytometric Determination of Actin Polymerization in Peripheral Blood Leukocytes Effectively Discriminate Patients With Homozygous Mutation in ARPC1B From Asymptomatic Carriers and Normal Controls

Actin nucleators initiate formation of actin filaments. Among them, the Arp2/3 complex has the ability to form branched actin networks. This complex is regulated by members of the Wiscott-Aldrich syndrome protein (WASp) family. Polymerization of actin filaments can be evaluated through flow cytometr...

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Bibliographic Details
Main Authors: Andreja N. Kopitar, Gašper Markelj, Miha Oražem, Štefan Blazina, Tadej Avčin, Alojz Ihan, Maruša Debeljak
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
ARPC1B deficiency
Arp2/3
actin polymerization
flow cytometry
functional test
peripheral blood leukocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01632/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01632/full

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